New research reported efficiency of flavonoid Fisetin as an effective anti-aging compound found in fruits and vegetables
Fisetin is a natural flavonoid that functions as an effective senolytic agent by eliminating damaged aging cells, improving health and extending lifespan. Human cells lose the ability to effectively divide and replicate after a period of time. Dead and damaged cells are eliminated by immune system such cells are called as senescent cells. Several anti-aging researchers hypothesize the build-up of these cells as fundamental to the development of many chronic age-related diseases.
Earlier in 2018, researchers revealed a combination of two existing drugs to effectively reduce the number of senescent cells in mouse experiments and extend the animal’s lifespan. The recent research examined ten different flavonoid compounds and discovered that fisetin displayed the most potent senotherapeutic effects in both mouse and human tissue experiments. The study was published in the journal EBioMedicine in October 2018.
One of the key innovations is the utilization of a technology called mass cytometry to observe functions of compound within an individual cell. This technology allowed the scientists to closely observe whether a tested treatment was effectively targeting specific senescent cells. As well as its ability to function as a potent senolytic agent, the study examined the effects of fisetin on both health and lifespan, particularly when administered at a late stage to elderly mice. The treatment successfully reduce a variety of age-related pathological biomarkers as well as extend the median lifespan of the animals.
However, the research is at nascent stages and verified in mice models. The natural origins of fisetin and its significant track record of safety in humans suggest the research should be able to rapidly move into human clinical trials offering further clarity on whether this treatment will offer anti-aging effects in elderly subjects.